Newcastle, who opened their European campaign with a 31-26 win over Worcester Warriors, name a starting XV which includes veteran full-back Mike Brown who makes his 250th Premiership appearance.

The Argentinian duo of Matias Orlando and Mateo Carreras are also named – the former making a first appearance of the season at centre for the Falcons. Hooker Charlie Maddison is also in line for his first start of the season against the table-toppers.

Gloucester Rugby host defending domestic champions Harlequins at Kingsholm Stadium. No.8 Ruan Ackermann makes his 100th appearance in the Cherry and White shirt alongside captain Lewis Ludlow and Jordy Reid in a formidable back row.

Head coach George Skivington makes two changes to the starting XV which beat Bath Rugby on Boxing Day – Billy Twelvetrees and Fraser Balmain brought into the line-up.

Gloucester face an uphill task qualifying from EPCR Challenge Cup’s Pool B having suffered defeat in their opening game against Lyon.

Saracens, another side who are yet to taste victory in the EPCR Challenge Cup this season, travel to Northampton Saints on Sunday.

Director of Rugby Mark McCall has made a quartet of changes to the side that earned victory against Worcester on Boxing Day – Jamie George and Harvey Beaton come into the front row for Ethan Lewis and Vincent Koch. Theo McFarland and Elliot Daly are also named in the XV.

There is a full schedule of TOP14 action over the weekend with an all-Pool C battle between Section Paloise and CA Brive the highlight.

EPCR Challenge Cup hopefuls Newcastle Falcons face a daunting trip to Heineken Champions Cup contenders – and Gallagher Premiership leaders – Leicester Tigers on Sunday.