England international back Watson, who has scored 13 tries in 41 games in EPCR competitions, joined from Bath Rugby in the summer and comes in on the wing as one of eight changes to the Tigers team that beat Northampton Saints 41-21 last Saturday.

Centre Phil Cokanasiga, wing Kini Murimurivalu and scrum-half Ben Youngs are brought in as the other switches in the backs, while there is a fresh second row pairing of Harry Wells and Eli Snyman.

Flanker Olly Cracknell and prop Joe Heyes have also been called in, while South African fly-half Handré Pollard, a new recruit from Montpellier Hérault Rugby, could make his Tigers debut from the bench.

Saracens meanwhile have made just two changes to the XV that started their 41-39 triumph over Gloucester Rugby last Saturday, bringing in lock Callum Hunter-Hill and centre Nick Tompkins.

Another all-Heineken Champions Cup contest in the Premiership on Saturday sees Sale Sharks welcome Exeter Chiefs to the AJ Bell Stadium.

Flanker Tom Curry and prop Conie Oosthuizen both return for the hosts, with young full-back Joe Carpenter also starting for his Premiership debut, as director of rugby Alex Sanderson makes three alterations to the side that beat Bath 37-20 a fortnight ago.

A host of stars return for 2020 Heineken Champions Cup winners Exeter, including full-back Stuart Hogg, wing Jack Nowell and 2020 EPCR European Player of the Year Sam Simmonds at No.8.

Meanwhile, hooker Agustin Creevy, who will be aiming to replicate his prolific 2020/21 EPCR Challenge Cup campaign in this season’s Heineken Champions Cup, returns as London Irish tussle with Bath at the Gtech Community Stadium.

Elsewhere on Saturday, Heineken Champions Cup newcomers DHL Stormers host Edinburgh Rugby, who return to EPCR’s elite competition this season, in the United Rugby Championship (URC).

South Africa hooker Joseph Dweba will debut for DHL Stormers in Cape Town, and is one of several Springboks returning to the side, with centre Damian Willemse, flanker Deon Fourie and lock Salmaan Moerat all starting.

Edinburgh are bolstered by the returns of fly-half Blair Kinghorn, who is back from illness, hooker Stuart McInally, No.8 Nick Haining and flanker Hamish Watson, the latter two making their first starts of the season.

Munster Rugby, Ospreys and Cell C Sharks are the other Heineken Champions Cup outfits in URC action on Saturday.

Conor Phillips and Patrick Campbell start on the wings for their Munster and URC debuts respectively as the Irish province entertain Zebre Parma, while Ospreys are able to call on the half-back combination of Rhys Webb and Gareth Anscombe for the first time this season when they welcome Glasgow Warriors.

Lock Justin Basson comes in as the only change for South African team Cell C Sharks as they visit Dragons with the hope of building on their 42-37 win at Zebre a week ago.

Last season’s Heineken Champions Cup winners Stade Rochelais host three-time finalists Racing 92 in the pick of Saturday’s TOP 14 action.

ASM Clermont Auvergne take on Lyon at Stade Marcel Michelin in the only other all-Heineken Champions Cup clash, while Union Bordeaux-Bègles are at home to Stade Français Paris and Castres Olympique visit USAP.

Four Heineken Champions Cup clubs play on Sunday as Harlequins meet Northampton Saints at Twickenham Stoop in the Premiership, and Montpellier welcome Stade Toulousain in the TOP 14.

Anthony Watson is poised to make his Leicester Tigers debut when they travel to fellow Heineken Champions Cup side Saracens in the Gallagher Premiership on Saturday.