England international Itoje made five appearances in this year’s EPCR Challenge Cup as Saracens reached the semi-finals, but his side will return to the Heineken Champions Cup next season.

Sarries named a rotated side for the final day of the regular Premiership campaign and they were soundly beaten by Gloucester Rugby, but they have recalled their big names for the second semi-final of their season.

From the team which started their penultimate day victory over Northampton Saints, there are three changes, with lock Tim Swinson brought in as well as Max Malins and Sean Maitland on the wings.

Meanwhile, Quins, who were knocked out of this season’s Heineken Champions Cup by Montpellier Hérault Rugby in the Round of 16, have made two alterations from the XV for their final day defeat at Exeter Chiefs.

With Louis Lynagh missing out through injury, a reshuffle of the back three sees Cadan Murley and Tyrone Green start on the wings with Huw Jones at full-back.

Saturday’s other Premiership semi-final sees Heineken Champions Cup quarter-finalists Leicester Tigers welcome Northampton, who exited at the pool stage, to Mattioli Woods Welford Road.

Tigers have made four changes from their win against Wasps last week, with hooker Julián Montoya brought into the pack along with lock Harry Wells and flanker Tommy Reffell.

Dan Kelly comes in at inside centre with Guy Porter switching to the wing and Chris Ashton dropping out.

There are four tweaks for Saints from their final day thrashing of Newcastle Falcons, as wing Courtnall Skosan, No.8 Juarno Augustus, and props Emmanuel Iyogun and Ehren Painter are called in.

Lock Maro Itoje is set to make his 100th appearance for three-time European champions Saracens as they take on Harlequins in Saturday’s Gallagher Premiership semi-final at StoneX Stadium.