Jaco Taute is one of two South African players out of action for Munster
Munster Rugby have been hit with the news that South African lock Jean Kleyn is set to miss at least the next two months and won't be available for the Champions Cup quarter-final against Toulouse on 1 April.
Kleyn picked up a neck injury in last weekend's PRO12 triumph over the Dragons and has been told he will be out of action for between eight and 10 weeks. Fellow countryman Jaco Taute also picked up an injury in the same game and misses this weekend's top of the table clash with the Ospreys in Swansea.
Taute is set to undergo further tests on his shoulder and is expect to face a few weeks on the sidelines. In his absence, Francis Saili and Rory Scannell fill the centre positions with fit-again Darren Sweetnam on the wing.
Billy Holland will make his 150th appearance for Munster when he packs down in the second row, having been released from the Ireland Six Nations squad. Ian Keatley and John Ryan have also been released for a match that will determined which team sits on top of the PRO12 table next week - the Champions Cup or the Challenge Cup quarter-finalists.
Munster currently hold a one point lead over the Welsh region and were the last team to beat them in the PRO12 way back in November. The Ospreys are currently on a run of 13 games without a defeat and made European club history in the Challenge Cup pool stages when they became the first team to secure a maximum 30 points.
"This is the kind of game that you get excited about - a top-of-the-table clash on a Saturday afternoon. It's going to be physical, it'll be edgy, and it will be a tense 80 minutes, but we know what we've got to do," said Ospreys head coach Steve Tandy.
"This is a big couple of weeks for us now, with home games against Munster and Glasgow over the next two weekends then a trip to Edinburgh before the PRO12 breaks again. Munster have been on an incredible run and put themselves in the driving seat in the PRO12.
"They delivered some really impressive performances and results in the Champions Cup against top teams and they'll come to us full of confidence in their ability to win this game."
Ospreys: Dan Evans; Keelan Giles, Kieron Fonotia, Ashley Beck, Hanno Dirksen; Sam Davies, Tom Habberfield (captain); Nicky Smith, Scott Baldwin, Rhodri Jones, Lloyd Ashley, Rory Thornton, Olly Cracknell, Sam Underhill, James King
Replacements: Sam Parry, Paul James, Daniel Suter, Tyler Ardron, Dan Baker, Brendon Leonard, Luke Price, Ben John
Munster: Ian Keatley; Ronan O'Mahony, Francis Saili, Rory Scannell, Ronan O'Mahony; Tyler Bleyendaal (captain), Duncan Williams; Dave Kilcoyne, Rhys Marshall, John Ryan; Darren O'Shea, Billy Holland; Dave O'Callaghan, Tommy O'Donnell, Jack O'Donoghue
Replacements: Kevin O'Byrne, Peter McCabe, Stephen Archer, Dave Foley, Conor Oliver, Abrie Griesel, Dan Goggin, Andrew Conway
Champions Cup Quarter-Final
Saturday, 1 April
Munster Rugby v Toulouse - Thomond Park (17:45 kick-off)